Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01)

National Institute of Dental and Craniofacial Research
National Center for Complementary and Integrative Health
National Cancer Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institute on Drug Abuse
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of General Medical Sciences
Office of Dietary Supplements

  • Purpose: The purpose of this funding opportunity announcement (FOA) is twofold: (1) to stimulate basic and mechanistic science that facilitates the development of effective probiotics or pre-/probiotic combinations of relevance to human health and disease; and (2) determine biological outcomes for the evaluation of efficacy of pre/probiotics in appropriate test systems and animal models. This FOA encourages basic and mechanistic studies using in vitro, in vivo, ex vivo, and in silico models that focus on prebiotic/probiotic strain selectivity, interaction, and function. It will also encourage inter and multidisciplinary collaborations among scientists in a wide range of disciplines including nutritional science, immunology, microbiomics, genomics, other ‘-omic’ sciences, biotechnology, and bioinformatics.
  • Eligibility:
    • Number of Applications: Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time.  This means that the NIH will not accept:
      • A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
      • A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
      • An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101).
  • Letter of Intent: N/A
  • Application Receipt Date(s): Multiple dates, see announcement.
  • Award Amount: Application budgets are not limited but need to reflect the actual needs of the proposed project.
  • Project Period: Five years




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